Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

NB20

Sigma-Aldrich

Anti-AnkyrinG Mouse mAb (463)

liquid, ≥95% (SDS-PAGE), clone 463

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

463, monoclonal

Saggio

≥95% (SDS-PAGE)

Forma fisica

liquid

contiene

≤0.1% sodium azide as preservative

Reattività contro le specie

rat, mouse, human, canine

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

do not freeze

Isotipo

IgG1

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ANK3(288)

Descrizione generale

Anti-Ankyrin G, mouse monoclonal, clone 463, recognizes the ~190 kDa ankyrin G protein in brain extracts. It is validated for Western blotting, immunofluorescence, and frozen sections.
Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with P3X63/Ag 8.653 mouse myeloma cells. Recognizes the ~190 kDa isoform of AnkyrinG.
Recognizes the ~190 kDa ankyrinG protein in brain extracts. Reacts with all spliced forms of ankyrinG.
  • Antibody Target Gene Symbol: ANK3
  • Target Synonym: 2900054D09RIK, AI314020, AnkG, Ankyrin-3, ANKYRIN-G, FLJ45464, MGC14049
  • Entrez Gene Name: ankyrin 3, node of Ranvier (ankyrin G)
  • Hu Entrez ID: 288 (Related Antibodies: AP1034, PC523, PC522, AP1057)
  • Mu Entrez ID: 11735
  • Rat Entrez ID: 361833

    • Immunogeno

    Human
    a synthetic peptide corresponding to amino acids from the spectrin-binding domain of human ankyrinG

    Applicazioni


    Frozen Sections (1-2 g/ml)
    Immunoblotting (2-5 g/ml)
    Immunofluorescence (1-2 g/ml)

    Confezionamento

    Please refer to vial label for lot-specific concentration.

    Attenzione

    Toxicity: Standard Handling (A)

    Stato fisico

    In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.

    Risultati analitici

    Positive Control
    Mouse or rat brain extract or unmyelinated axons

    Altre note

    AnkyrinG is a good immunohistochemical marker for axon initial segments, nodes of Ranvier, and epithelial cell-cell contact sites. Antibody should be titrated for optimal results in individual systems.
    Davis, J.Q., et al. 1995. Mol. Biol. Cell6, 177a, supplement.
    Kunimoto, M., et al. 1995. FEBS Lett.357, 217.
    Lambert, S., et al. 1995. Mol. Biol. Cell6, 98a supplement.
    Bennett, V. and Gilligan, D.M. 1993. Ann. Rev. Cell Biol.9, 27.
    Kunimoto, M., et al. 1991. J. Cell Biol.115, 1319.
    Otto, E., et al. 1991. J. Cell Biol.114, 241.
    Davis, J., and Bennett, V. 1984. J. Biol. Chem.259, 13550.

    Note legali

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

    Not finding the right product?  

    Try our Motore di ricerca dei prodotti.

    Codice della classe di stoccaggio

    10 - Combustible liquids

    Classe di pericolosità dell'acqua (WGK)

    nwg

    Punto d’infiammabilità (°F)

    Not applicable

    Punto d’infiammabilità (°C)

    Not applicable

    Certificati d'analisi (COA)

    Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

    Possiedi già questo prodotto?

    I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

    Visita l’Archivio dei documenti

    Dhaval Nanavati et al.
    Journal of neurochemistry, 119(3), 617-629 (2011-08-16)
    Bipolar disorder is a devastating illness that is marked by recurrent episodes of mania and depression. There is growing evidence that the disease is correlated with disruptions in synaptic plasticity cascades involved in cognition and mood regulation. Alleviating the symptoms
    Hongyan Zhu et al.
    Scientific reports, 6, 38108-38108 (2016-12-03)
    Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical
    Ruani N Fernando et al.
    Nature communications, 7, 12186-12186 (2016-07-21)
    Fast nerve conduction relies on successive myelin segments that electrically isolate axons. Segment geometry-diameter and length-is critical for the optimization of nerve conduction and the molecular mechanisms allowing this optimized geometry are partially known. We show here that peripheral myelin
    Wing Yan Yu et al.
    Stem cells and development, 24(5), 624-639 (2014-10-18)
    A growing body of evidence has revealed that stem-like cells in the posterior limbus of the eye between the corneal endothelium (CE) and trabecular meshwork (TM) may be able to rejuvenate these tissues in disease. However, these cells have not

    Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

    Contatta l'Assistenza Tecnica.