MABN2263

Anti-ZMYM2 Antibody, clone 9F12.1

clone 9F12.1, from mouse

• Sinonimo/i: Zinc finger MYM-type protein 2, Fused in myeloproliferative disorders protein, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: 9F12.1, monoclonal
• Reattività contro le specie: human
• Confezionamento: antibody small pack of 25 μg
• tecniche: western blot: suitable
• Isotipo: IgG2aκ
• N° accesso NCBI: NP_001177893
• N° accesso UniProt: Q9UBW7
• Condizioni di spedizione: ambient
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ZMYM2(7750)

Descrizione

Descrizione generale

Zinc finger MYM-type protein 2 (UniProt: Q9UBW7; also known as Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198) is encoded by the ZMYM2 (also known as FIM, RAMP, ZNF198) gene (Gene ID: 7750) in human. Zinc finger MYM-type protein 2 is a nuclear protein that may function as a transcription factor. Two isoforms of Zinc finger MYM-type protein 2 have been described that are produced by alternative splicing. The SUMO-interacting motifs (SIM) of Zinc finger MYM-type protein 2 are shown to be essential for its recruitment to chromatin. The SIM motifs play an important role in its gene-regulatory activities, however, they are not required for the intrinsic transcriptional repressive properties of Zinc finger MYM-type protein 2. A chromosomal aberration involving ZMYM2 is reported to cause stem cell leukemia lymphoma syndrome (SCLL), which is characterized as lymphoblastic lymphoma in association with a myeloproliferative disorder accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. (Ref.: Aguilar-Martinez, E., et al. (2015). Proc. Natl. Acad. Sci. USA. 112 (35); E4854-E4863).

Specificità

Clone 9F12.1 detects Zinc finger MYM-type protein 2 in human cells. It targets an epitope within 167 amino acids from the C-teminal region.

Immunogeno

GST/His-tagged recombinant fragment corresponding to 167 amino acids from the C-terminal region of human Zinc finger MYM-type protein 2.

Applicazioni

Anti-ZMYM2, clone 9F12.1, Cat. No. MABN2263, is a highly specific mouse monoclonal antibody that targets Zinc finger MYM-type protein 2 and has been tested in Western Blotting.

Qualità

Evaluated by Western Blotting in human hippocampus tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected ZMYM2 in human hippocampus tissue lysate.

Descrizione del bersaglio

~155 kDa observed; 154.91 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Stato fisico

Format: Purified

Altre note

Concentration: Please refer to lot specific datasheet.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): does not flash
• Punto d’infiammabilità (°C): does not flash