MAB1288

Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate

clone BB7.1, Chemicon^®, from mouse

• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: PE
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: BB7.1, monoclonal
• Reattività contro le specie: human
• Produttore/marchio commerciale: Chemicon^®
• tecniche: flow cytometry: suitable
• Isotipo: IgG1
• N° accesso NCBI: NM_005514.5
• N° accesso UniProt: P01889
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HLA-B(3106)

Descrizione

Descrizione generale

BIOCHEMISTRY: p I = 6.3

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a membrane-anchored heavy chain and a light chain (beta-2 microglobulin). HLA class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen and are expressed in nearly all cells. HLA-B7 is an HLA-B serotype. B7, previously HL-A7, is a serotype that identifies the more common HLA-B*07 gene products and was one of the first ′HL-A′ antigens recognized. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.

The previously assigned protein identifier P03989 has been merged into P01889. Full details can be found on the UniProt database.

Specificità

Binds to the HLA-B7 antigen. It does not bind to HLA-B27 or other related HLA antigens.

Cell type Reactivity
Homozygous HLA-B7 ++
Heterozygous HLA-B7 +
Heterozygous HLA-B27 -
Non-HLA-B7, B27 -

Immunogeno

Papain solubilized HLA-B7 antigen1

Applicazioni

Flow cytometry - Use 10 μL direct from the vial per 100 μL of whole blood, or 1 x 10E6 peripheral blood mononuclear cells (PBMC) in 100 μL buffer.

Optimal working concentrations must be determined by the end user.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

This Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate is validated for use in FC for the detection of HLA-B7.

Stato fisico

Protein A purified

Purified mouse immunoglobulin in phosphate buffered saline, pH 7.4, containing 0.2% bovine Serum albumin and 0.1% sodium azide.

Stoccaggio e stabilità

Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Widely expressed

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable