GF337

IL-4,
Human Recombinant Animal Free

• Sinonimo/i: Interleukin-4, IL4
• Codice UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

Proprietà

• Impurezze: <0.1 μg/mg protein endotoxin (<1 EU/μg)
• Livello qualitativo: 100
• N° accesso UniProt: P05112
• Condizioni di spedizione: dry ice

Descrizione

Descrizione generale

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naïve CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy.
Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

Product Source: Protein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.

Applicazioni

Research Category
Stem Cell Research

Research Sub Category
Growth Factors & Receptors

Qualità

Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.

Stato fisico

Product is presented without additives and is filtered through a 0.2 micron filter before lyophilization.

Stoccaggio e stabilità

Store at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable