580551

Tautomycin, Streptomyces spiroverticillatus

Tautomycin, CAS 109946-35-2, is a potent inhibitor of protein phosphatase 1, 2A, and smooth muscle endogenous phosphatase (IC₅₀ = 1 nM, 10 nM, and 6 nM, respectively). Mixture of two isomers.

• Sinonimo/i: Tautomycin, Streptomyces spiroverticillatus
• Formula empirica (notazione di Hill): C₄₁H₆₆O₁₃
• Numero CAS: 109946-35-2
• Peso molecolare: 766.95
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Forma fisica: lyophilized (thin film)
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated; protect from light
• Solubilità: chloroform: soluble; ethanol: soluble; methanol: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38+,41+/m0/s1; RFCWHQNNCOJYTR-IRCAEPKSSA-N

Descrizione

Descrizione generale

Mixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.

Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
PP1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively

Attenzione

Toxicity: Highly Toxic (H)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"

- removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase"

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

McCluskey, A., et al. 2002. J. Med. Chem.45, 1151.
Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun.287, 328.
Kikuchi, K., et al. 1999. Int. J. Mol. Med.4, 395.
Sheppeck, J.E., et al. 1997. J. Org. Chem.62, 387.
Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett.6, 3.
Gong, M.C., et al. 1992. J. Biol. Chem.267, 14662.
Suganuma, M., et al. 1992. Toxicon30, 873.
MacKintosh, C. and Klumpp, S. 1990. FEBS Lett.277, 137.
Magae, J., et al. 1989. J. Antibiot.42, 1290.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable