5.08507

Isradipine

• Sinonimo/i: Isradipine, L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
• Formula empirica (notazione di Hill): C₁₉H₂₁N₃O₅
• Numero CAS: 75695-93-1
• Peso molecolare: 371.39
• Numero MDL: MFCD00153820
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 100 mM; ethanol: 50 mM
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: N1C(=C(C(C(=C1C)C(=O)OC)c2c3n[o]nc3ccc2)C(=O)OC(C)C)C
• InChI: 1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3; HMJIYCCIJYRONP-UHFFFAOYSA-N

Descrizione

Descrizione generale

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Azioni biochim/fisiol

Primary Target
CaV

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Chan, C. S. et al. 2007. Nature.447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708.
Koschak, A. et al. 2003. J. Neurosci.23, 6041.
Koschak, A. et al. 2001. J. Biol Chem276, 22100.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable