420360-M

KMO Inhibitor I, Ro 61-8048

The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinonimo/i: KMO Inhibitor I, Ro 61-8048, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide
• Formula empirica (notazione di Hill): C₁₇H₁₅N₃O₆S₂
• Numero CAS: 199666-03-0
• Peso molecolare: 421.45
• Numero MDL: MFCD11040807
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥99% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 100 mg/mL; ethanol: 12.5 mg/mL
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19); NDPBMCKQJOZAQX-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (K_i = 4.8 nM; IC₅₀ = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Campesan, S., et al. 2011. Chem. Biol.21, 961.
Zwilling, D., et al. 2011. Cell145, 863.
Giorgini, F., et al. 2005. Nat. Genet.37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab.19, 771,
Rover, S., et al. 1997. J. Med. Chem.40, 4378.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3