23-034-M

p53 Protein, 10 µg

Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

• Sinonimo/i: Cellular tumour antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumour suppressor p53, TP53
• Codice UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

Proprietà

• Origine biologica: human
• Livello qualitativo: 100
• Ricombinante: expressed in E. coli
• Forma fisica: liquid
• Produttore/marchio commerciale: Upstate^®
• tecniche: activity assay: suitable
• Solubilità: water: soluble
• N° accesso Genebanck: BC003596
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... TP53(120407068)

Descrizione

Descrizione generale

Research area: Apoptosis

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli. The p53 protein is a tumor suppressor encoded by TP53 gene located on chromosome 17.

Applicazioni

Ubiquitination Cascade Comoponent: Substrate

Azioni biochim/fisiol

p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest, depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases, including choroid plexus papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.

Stato fisico

Purified using immobilized metal affinity chromatography.

Altre note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Note legali

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317
• Consigli di prudenza: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classi di pericolo: Skin Sens. 1
• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable