208920

Calmodulin Kinase IINtide

A potent and specific inhibitor of CaMK II (IC₅₀ = 50 nM for both the total and Ca²⁺-independent CaMK II activity).

• Sinonimo/i: Calmodulin Kinase IINtide, KRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
• Formula empirica (notazione di Hill): C₁₃₆H₂₄₀N₄₄O₃₉
• Peso molecolare: 3115.63
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: off-white
• Solubilità: DMSO: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A potent and specific inhibitor of CaMK II (IC₅₀ = 50 nM for both the total and Ca²⁺-independent CaMK II activity). Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC₅₀ range 100-400 nM). Does not affect the activities of CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of CaMK IIN.

A potent and specific inhibitor of calmodulin kinase II (CaM-KII) (IC₅₀ = 50 nM for both total and Ca²⁺-independent activities of CaM-KII). Does not affect the activities of CaM-KI, CaM-KIV, CaM-KK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of the inhibitory protein, CaM-KIIN. A cell-permeable version is available under Cat. No. 208921.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Cam Kinase-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 nM for both the total and Ca2+-independent CaMK II activity

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH

Stato fisico

Supplied as a trifluoroacetate salt.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Altre note

Soderling, T.R., et al. 2001. J. Biol. Chem.276, 3719.
Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA95, 10890.
Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA95, 13272.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable