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Cellvento® 4CHO-X COMP

expansion medium

Produzione farmaceutica

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About This Item

Codice UNSPSC:
41106213

Livello qualitativo

500

Descrizione

shipped with cooling packs

Nome Commerciale

Cellvento®

Forma fisica

dry powder

tecniche

cell culture | mammalian: suitable (suspension)

Temperatura di conservazione

2-8°C

Categorie correlate

Descrizione generale

There are several advantages to using perfusion in your seed train, namely, flexibility in your production processes, increase in capacity and footprint reduction. Reducing the number of bioreactors in your seed train leads to a better utilization and eliminates traditional bottlenecks (compressed seed train). Additionally, using N-1 perfusion enables the inoculation of a production bioreactor with higher cell densities for high seed production process formats. Cellvento® 4CHO-X Expansion Medium has been specifically developed for N-1 perfusion for Chinese Hamster Ovary (CHO) cell lines. It is formulated with a high nutrient concentration to achieve low cell specific perfusion rates (CSPRs) at high cell densities. The medium is chemically defined, of non-animal origin, and contains no hydrolysates or components of unknown composition.

Applicazioni

Cellvento® 4CHO-X Expansion Medium has been specifically formulated to control the metabolic profile of the cells, both to minimize toxic byproducts and to ensure adequate nutrient levels for high cell densities. Preventing nutrient depletion can increase robustness and predictability of seed train operations. This medium supports high growth and viability, thus increasing cell biomass for cryopreservation or inoculation of another reactor. The medium addresses seed train intensification and shows a positive impact in IgG production, when combined in perfusion production with EX-CELL® Advanced HD Perfusion medium (24370C), and in Fed-batch production with e.g. Cellvento® 4CHO medium (103795) and Cellvento® 4Feed (103796). It is expected to work with other media platforms as well. Cellvento® 4CHO-X Expansion Medium can be used for all seed train expansion steps including N-1, reaching robust growth at low CSPRs. This product is intended for research or further manufacturing but not for human or therapeutic use.

Quantità

Formulated to contain 26.2 grams of powder per liter of medium.

Note legali

CELLVENTO is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Articoli

Reproducible Scaling of a Cell Retention Filter Using the Cellicon® Cell Retention Solution

This page describes the design attributes of the Cellicon® filter assembly for cell retention and how they simplify scale-up of intensified upstream processes.

Operational and Financial Advantages of Cellicon® Cell Retention Solution in an N-1 Perfusion Process

This page describes the financial and operational advantages offered by the Cellicon® Cell Retention Device in an N-1 perfusion process at the 2,000 L scale in comparison to a cell retention device from another supplier.

Seed Train Intensification Using High Cell Density Cryopreservation

High cell density cryopreservation (HCDC) is a closed processing alternative to the traditional seed train expansion process. Learn more about the benefits of HCDC.

Establishing the First GMP Guideline for Cell Culture Media

Cell culture media are vital for bioprocessing therapeutics. This page describes the central role of our organization in authoring purpose-built GMP for cell culture media.

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Contenuto correlato

Production and Harvest Intensification

Biopharmaceutical developers need efficient, productive upstream processes that deliver high quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification can future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.

Seed Train Intensification

Biopharmaceutical developers need efficient, productive upstream processes that deliver high quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification can future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.

Intensificazione della produzione e della raccolta

Coloro che sviluppano i processi biofarmaceutici ha l’esigenza di mettere a punto processi produttivi upstream efficienti, in grado di fornire anticorpi monoclonali (mAb) e altre proteine ricombinanti di alta qualità. L'intensificazione del processo può preparare sin da oggi le loro strategie produttive alle sfide future e, nello stesso tempo, ridurre i costi e incrementare la versatilità degli impianti.

Intensificazione del seed train

Gli sviluppatori biofarmaceutici necessitano di processi upstream efficienti e produttivi che assicurino anticorpi monoclonali (mAb) e altre proteine ricombinanti di alta qualità. L'intensificazione del processo può preparare sin da oggi le loro strategie produttive alle sfide future e, nello stesso tempo, ridurre i costi e incrementare la versatilità degli impianti.

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