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Merck
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Documenti

09-144

Sigma-Aldrich

Anti-phospho-Brk (Tyr342) Antibody

Upstate®, from rabbit

Sinonimo/i:

PTK6, protein tyrosine kinase 6, breast tumor kinase, protein-tyrosine kinase BRK

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

human

Produttore/marchio commerciale

Upstate®

tecniche

western blot: suitable

Isotipo

IgG

N° accesso NCBI

NM_005975.2

N° accesso UniProt

Q13882

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

phosphorylation (pTyr342)

Informazioni sul gene

human ... PTK6(5753)

Specificità

Recognizes human phospho-Brk at tyrosine 342.

Immunogeno

KLH conjugated synthetic peptide corresponding to amino acids encompassing Tyr342 of human Brk.

Applicazioni

Anti-phospho-Brk (Tyr342) Antibody is an antibody against phospho-Brk (Tyr342) for use in WB.
Research Category
Apoptosis & Cancer
Research Sub Category
Tumor Markers

Qualità

Routinely evaluated by immunoblot.

Descrizione del bersaglio

~50 kDa

Stato fisico

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Priya S Mathur et al.
Molecular cancer research : MCR, 14(6), 563-573 (2016-03-18)
Disruption of the gene encoding Protein Tyrosine Kinase 6 (Ptk6) delayed differentiation and increased growth in the mouse intestine. However, Ptk6-null mice were also resistant to azoxymethane-induced colon tumorigenesis. To further explore functions of PTK6 in colon cancer, expression of
L Liu et al.
Oncogene, 25(35), 4904-4912 (2006-03-29)
Breast tumor kinase (Brk) is a non-receptor tyrosine kinase distantly related to the Src family kinase. It is expressed in more than 60% of breast tumors, but the biological role of this kinase remains to be determined. Only a limited
Chaoqun Liu et al.
Journal of experimental & clinical cancer research : CR, 40(1), 297-297 (2021-09-24)
Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) is aberrantly overexpressed in clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to the chemoresistance of CRC in human
Milica B Gilic et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188432-188432 (2020-09-22)
Protein tyrosine kinase 6 (PTK6) is the most well studied member of the PTK6 family of intracellular tyrosine kinases. While it is expressed at highest levels in differentiated cells in the regenerating epithelial linings of the gastrointestinal tract and skin
Haoqun Qiu et al.
Oncogene, 24(36), 5656-5664 (2005-05-05)
Breast tumor kinase (Brk) is a member of the Frk family of nonreceptor tyrosine kinases that is overexpressed in a high percentage of human breast tumors. The downstream substrates and effectors of Brk remain largely unidentified. In this study, we
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