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M-152

Supelco

Mitragynine solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formula empirica (notazione di Hill):
C23H30N2O4
Numero CAS:
4098-40-2
Peso molecolare:
398.50
Numero CE:
200-659-6
Numero MDL:
MFCD09838906
Codice UNSPSC:
41116107
ID PubChem:
329817883
NACRES:
NA.24

Grado

certified reference material

Forma fisica

liquid

Caratteristiche

Snap-N-Spike®/Snap-N-Shoot®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

100 μg/mL in methanol

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

forensics and toxicology

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

O=C(OC)/C([C@H]1C[C@@](N(C[C@H]1CC)CC2)([H])C3=C2C(C(OC)=CC=C4)=C4N3)=C/OC

InChI

1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1
LELBFTMXCIIKKX-QVRQZEMUSA-N

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Descrizione generale

Mitragynine, commonly known as Kratom, is the most abundant alkaloid in the plant Mitragynine speciosa. Sold over the internet as herbal plant extracts, Kratom is noted for its psychoactive, stimulant, and sedative effects depending on the dosage level. According to DEA′s Drugs and Chemicals of Concern page, mitragynine use can lead to addiction with adverse effects ranging from anorexia and weight loss to hallucinations and delusion.

Applicazioni



  • Pharmacokinetic Interaction of Kratom and Cannabidiol: A study analyzed the pharmacokinetic interactions between mitragynine and cannabidiol in male rats, providing critical insights for co-administration of these compounds (Berthold et al., 2024).


  • Enhancement of Low-Dose Doxorubicin Cytotoxicity by Kratom Extracts: Research investigated whether kratom extracts enhance the cytotoxic effects of low-dose doxorubicin against lung cancer cells, suggesting a potential use of mitragynine in cancer therapy (Bayu et al., 2024).


  • Extraction and Detection of Mitragynine: A technique using high-performance liquid chromatography for the extraction and detection of mitragynine from Kratom leaves was developed, enhancing the accuracy and efficiency of mitragynine isolation for research purposes (Ng and Ha, 2024).


  • Amelioration of Mitragynine Withdrawal Symptoms: A study explored the potential of an epigenetic mechanism to ameliorate withdrawal behavior and cognitive impairments caused by mitragynine, contributing to better management strategies for opioid withdrawal symptoms (Yunusa et al., 2024).


  • Imaging Mass Spectrometry Analysis of Mitragynine: Research utilized MALDI imaging mass spectrometry to study the distribution of Mitragyna speciosa alkaloids, including mitragynine, in dosed rat brain tissue, advancing the understanding of its biochemical behavior (Liang et al., 2024).


Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H311 + H331,H370

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organi bersaglio

Eyes,Central nervous system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

49.5 °F - closed cup

Punto d’infiammabilità (°C)

9.7 °C - closed cup

Certificati d'analisi (COA)

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Juraithip Wungsintaweekul et al.
Biotechnology letters, 34(10), 1945-1950 (2012-06-21)
Mitragynine is a pharmacologically-active terpenoid indole alkaloid found in Mitragyna speciosa leaves. Treatment with methyl jasmonate (10 μM) for 24 h and yeast extract (0.1 mg/ml) for 12 h were the optimum conditions of elicitation of mitragynine accumulation in a
Isabel P Kerschgens et al.
Chemical communications (Cambridge, England), 48(100), 12243-12245 (2012-11-15)
The pharmacologically interesting indole alkaloids (-)-mitragynine, (+)-paynantheine and (+)-speciogynine were synthesised in nine steps from 4-methoxytryptamine by a route featuring (i) an enantioselective thiourea-catalysed Pictet-Spengler reaction, providing the tetrahydro-β-carboline ring and (ii) a Pd-catalysed Tsuji-Trost allylic alkylation, closing the D-ring.
Anika A Philipp et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(15-16), 1049-1055 (2011-04-01)
Mitragyna speciosa (Kratom in Thai), native in Southeast Asia, is increasingly misused as a herbal drug of abuse. During metabolism studies on the Kratom alkaloids mitragynine, its diastereomers speciogynine and speciociliatine as well as paynantheine in rats and humans, further
Michael F Neerman et al.
Journal of forensic sciences, 58 Suppl 1, S278-S279 (2012-10-23)
A 17-year-old white man who showed no obvious signs of trauma was found unresponsive in bed and was pronounced dead at the scene. The decedent had a documented history of heroin abuse and chronic back pain and reportedly self-medicated with
Robert Kronstrand et al.
Journal of analytical toxicology, 35(4), 242-247 (2011-04-26)
The leaves of Kratom, a medicinal plant in Southeast Asia, have been used as an herbal drug for a long time. At least one of the alkaloids present in Kratom, mitragynine, is a mu-receptor agonist. Both Kratom and an additional
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