N8105
Nipecotamide
95%
Sinonimo/i:
3-Carbamoylpiperidine, 3-Piperidinecarboxamide
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About This Item
Formula empirica (notazione di Hill):
C6H12N2O
Numero CAS:
Peso molecolare:
128.17
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
Prodotti consigliati
Saggio
95%
Stato
solid
Punto di fusione
103-106 °C (lit.)
Stringa SMILE
NC(=O)C1CCCNC1
InChI
1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9)
BVOCPVIXARZNQN-UHFFFAOYSA-N
Applicazioni
Reactant for synthesis of:
- DPP-4 inhibitors
- IKKβ inhibitors
- Spiroimidazolidinone NPC1L1 inhibitors
- Sulfamides
- Phosphodiesterase 5 inhibtors
- Anti-HIV agents
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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S Puglisi-Allegra et al.
Psychopharmacology, 70(3), 287-290 (1980-01-01)
An inhibitor of GABA-T (sodium n-dipropylacetate), a GABA agonist (muscimol hydrobromide) and an inhibitor of GABA uptake (R,S) nipecotic acid amide were administered to DBA/2 isolated aggressive mice throughout three successive daily experimental sessions. Aggressive responses, measured by an automated
Relationships between the chemical constitution of carbamoylpiperidines and related compounds, and their inhibition of ADP-induced human blood platelet aggregation.
R P Quintana et al.
Thrombosis research, 22(5-6), 665-680 (1981-06-01)
Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.
C Zhou et al.
Bioorganic & medicinal chemistry letters, 11(3), 415-417 (2001-02-24)
N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the somatostatin subtype-2 receptor in vitro. For example iso-nipecotic amide 8a showed high hsst2 binding affinity (Ki = 0.5 nM) and
A Depaulis et al.
Psychopharmacology, 83(4), 367-372 (1984-01-01)
When GABA-potentiating compounds were administered IP to rats with prior experience of mouse-killing behaviour, a reduction of killing was observed with gamma-vinyl GABA (200 and 400 mg/kg) and nipecotic acid amide (400 mg/kg), while no significant effect was noted following
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