H125
Harmalol hydrochloride dihydrate
monoamine oxidase inhibitor
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About This Item
Formula empirica (notazione di Hill):
C12H12N2O · HCl · 2H2O
Numero CAS:
Peso molecolare:
272.73
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
Prodotti consigliati
Controllo stupefacenti
regulated under CDSA - not available from Sigma-Aldrich Canada
Punto di fusione
264-267 °C (dec.) (lit.)
Stringa SMILE
Cl[H].[H]O[H].[H]O[H].CC1=NCCc2c1[nH]c3cc(O)ccc23
InChI
1S/C12H12N2O.ClH.2H2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12;;;/h2-3,6,14-15H,4-5H2,1H3;1H;2*1H2
OYKGNQNESCZSHQ-UHFFFAOYSA-N
Azioni biochim/fisiol
Harmalol, a harmala (β-carboline) alkaloid, is a monoamine oxidase inhibitor (MAOi) useful for studies involving melanogenesis. Harmalol is use in β-carboline nucleic acid (DNA and RNA) binding studies.
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Ji-Hyun Im et al.
Vascular pharmacology, 50(5-6), 147-152 (2008-12-17)
Beta-carboline alkaloids including harmalol, harmaline, norharmane, harmol, harmine and harmane are important constituents of the medicinal plant, Perganum harmala L. (Zygophylaceae), which has been used in traditional medicine. In the present study, the antiplatelet activities of six beta-carboline alkaloid compounds
Najma Arshad et al.
Phytotherapy research : PTR, 22(11), 1533-1538 (2008-09-25)
In the present study the antimicrobial potential of various extracts from 12 medicinal plants has been investigated in vitro on multiple antibiotic resistant pathogens and some selected protozoa isolated from poultry. The initial examination was performed on E. coli (n
S Y Tse et al.
Biochemical pharmacology, 42(3), 459-464 (1991-07-15)
beta-Carboline alkaloids are derived as a result of condensation between indoleamine (e.g. tryptamine) and short-chain carboxylic acid (e.g. pyruvic acid) or aldehyde (e.g. acetaldehyde), a reaction that occurs readily at room temperature. These compounds have been found endogenously in human
C C Shi et al.
Japanese journal of pharmacology, 85(3), 299-305 (2001-04-28)
Three psychological active principles from the seeds of Peganum harmala L., harmine, harmaline and harmalol, showed vasorelaxant activities in isolated rat thoracic aorta preparations precontracted by phenylephrine or KCl with rank order of relaxation potency of harmine > harmaline >
M Kartal et al.
Journal of pharmaceutical and biomedical analysis, 31(2), 263-269 (2003-03-01)
A simple and sensitive method for separation and determination of harmol, harmalol, harmine and harmaline has been developed and validated. Harmol, harmalol, harmine and harmaline were separated using a Metasil ODS column by isocratic elution with flow rate 1.5 ml/min.
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