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Sigma-Aldrich

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit

for CIJ synthesis of nanoparticles

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About This Item

Codice UNSPSC:
12162002
NACRES:
NA.21

Temperatura di conservazione

2-8°C

Categorie correlate

Applicazioni

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit is a ready to use nanoformulation kit for flash nanoprecipitation synthesis of PEGylated PLA nanoparticles for drug delivery research applications. This kit contains rationally selected PEGylated PLA polymers and stabilizer, enabling users to screen and select nanoformulations without the need for lenghty trial and error optimization. These PEGylated PLA polymers have been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.

This kit has been curated and designed for flash nanoprecipitiaton (FNP) nanoparticle synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.

Caratteristiche e vantaggi

  • Ready-to-use nanoformulation kit for PEGylated nanoparticles
  • Step-by-step flash nanoprecipitation protocol
  • Create specifically sized, biodegradable, PEGylated PLA nanoparticles
  • Maximize the encapsulation of hydrophobic drugs
  • Two different PEGylated PLAs are included
  • Optimized for 60 nm-150 nm nanoparticles
A flash nanoprecipitation protocol to prepare drug-encapsulated nanoparticles using the NanoFabTx™ NanoFlash CIJ Mixer is included and can be found under the Protocol section of this page.

Note legali

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Jing Han et al.
Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
Byung Kook Lee et al.
Advanced drug delivery reviews, 107, 176-191 (2016-06-06)
Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are
Nazila Kamaly et al.
Chemical Society reviews, 41(7), 2971-3010 (2012-03-06)
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
C Thomasin et al.
Journal of pharmaceutical sciences, 87(3), 269-275 (1998-04-02)
Phase separation (frequently called coacervation) of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) is a classical method for drug microencapsulation. Here, attempts have been made to describe this process in the light of thermodynamics. Different PLA/PLGAs were dissolved in either dichloromethane or
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