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920673

Sigma-Aldrich

1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid

Sinonimo/i:

Rigid linker for PROTAC® development

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About This Item

Formula empirica (notazione di Hill):
C14H21N3O4
Numero CAS:
1422386-02-4
Peso molecolare:
295.33
Numero MDL:
MFCD25371800
Codice UNSPSC:
12352106
NACRES:
NA.22

Forma fisica

powder

Livello qualitativo

100

Impiego in reazioni chimiche

reagent type: linker

Gruppo funzionale

Boc
carboxylic acid

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)(OC(N1CCCC(N2C=C(C(O)=O)C=N2)C1)=O)C

Categorie correlate

Applicazioni

1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920533
920649
920665
920703

Altre note

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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N° Catalogo
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((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)proline

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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