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918962

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)

PEG average Mn 5000, PDLA average Mn 50000

Sinonimo/i:

Biodegradable, Block copolymer, Drug delivery, PEG-PLA, PLLA, mPEG-PLA, mPEG-PLLA

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About This Item

Formula condensata:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
Codice UNSPSC:
12352106
NACRES:
NA.23

Forma fisica

solid

Livello qualitativo

100

PM

PDLA average Mn 50,000 (by NMR)
PDLA average Mn 50000
PEG average Mn 5,000 (by NMR)
PEG average Mn 5000

Colore

white to yellow

Temperatura di conservazione

2-8°C

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Applicazioni

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide) is an amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

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Cynthia Griggins et al.
HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues, 23(1), 43-56 (2010-12-21)
This essay describes and critically evaluates a co-operative educational program to train Ugandan health care workers in bioethics. It describes one "bottom-up" effort, a week-long intensive workshop in bioethics provided by the authors to health care professionals in a developing
Ren Zhong Xiao et al.
International journal of nanomedicine, 5, 1057-1065 (2010-12-21)
Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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