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901422

Sigma-Aldrich

Poly(N-isopropylacrylamide)

average Mn 85,000

Sinonimo/i:

NIPAM polymer, PNIPAM, PolyNIPAM, Polyacrylamide, polyNIPAM

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About This Item

Formula condensata:
CH3(C6H11NO)nCH3
Numero CAS:
25189-55-3
Numero MDL:
MFCD00284282
Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

crystals

PM

Mn 60,000-110,000 Da by MALLS (GPC)
average Mn 85,000

Colore

white to off-white

Punto di fusione

96 °C

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)
WDFKEEALECCKTJ-UHFFFAOYSA-N

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Descrizione generale

Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.
Poly(N-isopropylacrylamide) (PNIPAM) is a thermo-sensitive polymer with a low critical solution temperature (LCST). It exhibits both hydrophobic and hydrophilic characteristics below and above the LCST. It forms microgels, typically by free-radical precipitation polymerization.

Applicazioni

PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries. It can also be used in the fabrication of molecular nanothermometer. PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS).
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
Au@ pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis
Alvarez-Puebla RA, et al.
Angewandte Chemie (International ed. in English), 48(1), 138-143 (2009)
Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Poly (N-isopropylacrylamide)(PNIPAM) is never hydrophobic
Pelton R, et al.
Journal of Colloid and Interface Science, 348(2), 673-674 (2010)
Conductive ?smart? hybrid hydrogels with PNIPAM and nanostructured conductive polymers
Shi Y, et al.
Advances in Functional Materials, 25(8), 1219-1225 (2015)
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