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Merck
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Documenti

764825

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG Mn 2,000, PLGA Mn 4,500

Sinonimo/i:

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA

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About This Item

Formula condensata:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

pellets

Rapporto d’alimentazione

lactide:glycolide 65:35

PM

PEG Mn 2,000
PLGA Mn 4,500
average Mn 6,500 (total)

Tempo di degradazione

1-4 weeks

Temp. transizione

Tm 241-246 °C

Ind. polidispersione

≤2.0

Temperatura di conservazione

2-8°C

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Descrizione generale

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.

Applicazioni

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
forming "stealth" pegylated microparticles

Caratteristiche e vantaggi

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Thermosensitive self-assembling block copolymers as drug delivery systems.
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymer, 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., & Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

Articoli

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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