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764752

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA Mn 55,000

Sinonimo/i:

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA, mPEG-b-PLGA

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About This Item

Formula condensata:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
Codice UNSPSC:
12162002
NACRES:
NA.23

Descrizione

typical PEG PDI < 1.1; overall PDI < 2.5

Forma fisica

pellets

Rapporto d’alimentazione

lactide:glycolide 50:50

PM

PEG average Mn 5,000
PLGA Mn 55,000
average Mn 60,000 (total)

Tempo di degradazione

1-4 weeks

Temp. transizione

Tg 10 °C(lit.)
Tm 254-259 °C

Ind. polidispersione

<1.2

Temperatura di conservazione

2-8°C

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Descrizione generale

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.

Applicazioni

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Caratteristiche e vantaggi

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Hunter Bachman et al.
Lab on a chip, 20(7), 1238-1248 (2020-02-28)
Whether reagents and samples need to be combined to achieve a desired reaction, or precise concentrations of solutions need to be mixed and delivered downstream, thorough mixing remains a critical step in many microfluidics-based biological and chemical assays and analyses.
Thermosensitive self-assembling block copolymers as drug delivery systems
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymers (Basel, Switzerland), 3(2), 779-811 (2011)
Sara Moufarrij et al.
Scientific reports, 10(1), 3470-3470 (2020-02-28)
Novel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained

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