6-Hydroxyflavanone is poorly soluble in water but is soluble in dimethyl sulfoxide (DMSO) at a concentration of 47 mg/mL.
419796
6-Hydroxyflavanone
99%
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1 G
34,23 €
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1 G
34,23 €
About This Item
Formula empirica (notazione di Hill):
C15H12O3
Numero CAS:
Peso molecolare:
240.25
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22
34,23 €
Prezzo di listino48,90 €Risparmia il 30%Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Prodotti consigliati
Livello qualitativo
Saggio
99%
Stato
solid
Punto di fusione
220-222 °C (dec.) (lit.)
Gruppo funzionale
ketone
phenyl
Stringa SMILE
Oc1ccc2OC(CC(=O)c2c1)c3ccccc3
InChI
1S/C15H12O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-8,15-16H,9H2
XYHWPQUEOOBIOW-UHFFFAOYSA-N
Informazioni sul gene
rat ... Ar(24208)
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Categorie correlate
Descrizione generale
6-Hydroxyflavanone is a flavonoid.[1] Its biotransformation by Aspergillus niger strains have been described.[2] Crystal structure of S and R enantiomers of 6-hydroxyflavanone has been reported to have four crystallographic sites of the unit cell in an approximate 3:1/1:3 ratio.[3] It was identified as a metabolite of flavnone on incubation with rat liver microsomes by positive ion electrospray LC/MS analysis.[4]
Applicazioni
6-Hydroxyflavanone (6-HF) has been used for the enantiomeric separation of flavonoids using polysaccharide-based chiral stationary phases by nano-liquid chromatography (nano-LC).[1] Racemic 6-HF may be used in the synthesis of 6-propionoxy-flavanone (6-PF). 6-HF may be employed as synthetic flavone to investigate the mechanism of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced cytotoxic and apoptotic effects in HeLa cancer cells.[5]
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Disordered 6-hydroxyflavanone.
Bialonska A, et al.
Acta Crystallographica Section E, Structure Reports Online, 63(2), 430-431 (2007)
Dejan Nikolic et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(4), 387-397 (2004-03-25)
Flavonoids represent a diverse group of natural pigments widely distributed in the plant kingdom and are an important component of human diet due to their high content in fruits and vegetables. Since many flavonoids have been shown to be potent
Microbial transformations of flavanone and 6-hydroxyflavanone by Aspergillus niger strains.
Kostrzewa-Suslow E, et al.
Journal of Molecular Catalysis. B, Enzymatic, 39(1), 18-23 (2006)
Ewelina Szliszka et al.
Molecules (Basel, Switzerland), 17(10), 11693-11711 (2012-10-03)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as the most promising anticancer agent in the TNF superfamily because of its selective cytotoxicity against tumor cells versus normal primary cells. However, as more tumor cells are reported to be resistant
Tomohide Uno et al.
Biopharmaceutics & drug disposition, 36(8), 552-563 (2015-07-30)
CYP2A6 is a major hepatic member of the cytochrome P450 family in humans. Much variation in CYP2A6 levels and activity can be attributed to genetic polymorphisms of this gene. CYP2A6*25 comprises an amino acid substitution, F118L. To clarify the effect
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What are the solvents that can be used to dissolve 6-Hydroxyflavanone ?
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