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133310

Sigma-Aldrich

Aniline hydrochloride

97%

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About This Item

Formula condensata:
C6H5NH2 · HCl
Numero CAS:
142-04-1
Peso molecolare:
129.59
Beilstein:
3593823
Numero CE:
205-519-8
Numero MDL:
MFCD00012958
Codice UNSPSC:
12352100
ID PubChem:
24848100

Densità del vapore

4.46 (vs air)

Saggio

97%

Punto di fusione

196-198 °C (lit.)

Stringa SMILE

Cl.Nc1ccccc1

InChI

1S/C6H7N.ClH/c7-6-4-2-1-3-5-6;/h1-5H,7H2;1H
MMCPOSDMTGQNKG-UHFFFAOYSA-N

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Applicazioni

Aniline hydrochloride was used in the preparation of polyaniline coated poly(styrene-co-styrene sulfonate) nanoparticles. It was used to study the induction of Nei-like DNA glycosylases (NEIL1/2)-mediated base excision repair(BER) in rat spleen and 8-oxoguanine glycosylase 1-mediated BER due to aniline exposure.

Azioni biochim/fisiol

The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Altre note

This product has been replaced by A8524-ALDRICH | Aniline hydrochloride ≥99%

Sostituito da

N° Catalogo
Descrizione
Determinazione del prezzo

A8524

Aniline hydrochloride, ≥99%

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Muta. 2 - Skin Sens. 1 - STOT RE 1

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

381.2 °F - closed cup

Punto d’infiammabilità (°C)

194 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
S47387
06014BH
S39880
02301BV
15923CE

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Preparation of PANI-coated poly (styrene-co-styrene sulfonate) nanoparticles.
Kim BJ, et al.
Polymer, 43(1), 111-116 (2002)
Huaxian Ma et al.
Toxicology and applied pharmacology, 251(1), 1-7 (2010-12-15)
The mechanisms by which aniline exposure elicits splenotoxic response, especially the tumorigenic response, are not well-understood. Earlier, we have shown that aniline-induced oxidative stress is associated with increased oxidative DNA damage in rat spleen. The base excision repair (BER) pathway
Dongdong Liang et al.
Chemical communications (Cambridge, England), 49(2), 173-175 (2012-11-22)
An efficient synthesis of free (NH)-phenanthridinones through Pd-catalyzed C(sp(2))-H aminocarbonylation of unprotected o-arylanilines under an atmospheric pressure of CO has been developed. Some ortho heteroarene substituted anilines as well as N-alkyl protected o-arylanilines are also suitable substrates for this C-H
Timo Stahl et al.
Journal of the American Chemical Society, 135(4), 1248-1251 (2013-01-15)
Heterolytic splitting of the Si-H bond mediated by a Ru-S bond forms a sulfur-stabilized silicon cation that is sufficiently electrophilic to abstract fluoride from CF(3) groups attached to selected anilines. The ability of the Ru-H complex, generated in the cooperative
Conghui Tang et al.
Journal of the American Chemical Society, 134(46), 18924-18927 (2012-11-08)
A novel and efficient copper-catalyzed azidation reaction of anilines via C-H activation has been developed. This method, in which the primary amine acts as a directing group by coordinating to the metal center, provides ortho azidation products regioselectively under mild
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