122912
2-Amino-6,8-dihydroxypurine
Sinonimo/i:
2-Amino-6,8-purinediol, 8-Hydroxyguanine
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About This Item
Formula empirica (notazione di Hill):
C5H5N5O2
Numero CAS:
Peso molecolare:
167.13
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
Prodotti consigliati
Impurezze
<10% acetic acid
Stringa SMILE
Nc1nc(O)c2[nH]c(O)nc2n1
InChI
1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)
CLGFIVUFZRGQRP-UHFFFAOYSA-N
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
235.4 °F - closed cup
Punto d’infiammabilità (°C)
113 °C - closed cup
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DNA repair, 12(10), 856-863 (2013-07-31)
Accumulation of 8-oxo-7,8-dihydroguanine (8-oxoG) in the DNA results in genetic instability and mutagenesis, and is believed to contribute to carcinogenesis, aging processes and various aging-related diseases. 8-OxoG is removed from the DNA via DNA base excision repair (BER), initiated by
Sara Timpano et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 5716-5728 (2019-01-17)
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Eleonora Parlanti et al.
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Although oxidatively damaged DNA is repaired primarily via the base excision repair (BER) pathway, it is now evident that multiple subpathways are needed. Yet, their relative contributions and coordination are still unclear. Here, mouse embryo fibroblasts (MEFs) from selected nucleotide
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