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Merck

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Sinonimi:
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Specie:
ID UniProtKB:
ID gene:
  • Human(5743) Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
  • Mouse(19225) prostaglandin-endoperoxide synthase 2
  • Rat(29527) prostaglandin-endoperoxide synthase 2
  • Goat(100860905) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • cow(282023) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(791253) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(100126581) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • dog(442942) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Domestic Rabbit(100009248) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443460) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • naked mole-rat(101704771) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • chicken(396451) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100135607) prostaglandin-endoperoxide synthase 2

Custom & Knockdown Gene Products

ELISA

Numero di prodotto
Descrizione
Specie
Human COX-2 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Specie
human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
COX-2 (SP21) Rabbit Monoclonal Antibody, ,
Reattività con
human
Applicazione
immunohistochemistry
Anti-Cox2 antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-COX-2 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM348, purified immunoglobulin,
Reattività con
human
Applicazione
immunohistochemistry
Anti-Cyclooxygenase-2 Antibody, Chemicon®, from rabbit,
Reattività con
bovine, human, mouse, sheep
Applicazione
ELISA
western blot
Anti-COX2 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human
Applicazione
ELISA
immunofluorescence

immunohistochemistry

western blot

Small Molecule - Blocker

Numero di prodotto
Descrizione
Specie
N-p-Tosyl-L-phenylalanine chloromethyl ketone, ≥97% (TLC), powder,
Specie
human

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
Celecoxib, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Aceclofenac, ≥98% (HPLC),
Specie
human
Etoricoxib, VETRANAL®, analytical standard,
Specie
human
Carprofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Carprofen, ≥97% (HPLC),
Specie
human

Proteins

Numero di prodotto
Descrizione
Specie
Cyclooxygenase 2 human, ≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein,
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human PTGS2,
Specie
human
MISSION® esiRNA, targeting mouse Ptgs2,
Specie
mouse