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Merck

PRKG1

protein kinase, cGMP-dependent, type I

Sinonimi:
1, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha
Specie:
Human PRKG1 (5592), Mouse Prkg1 (19091), Rat Prkg1 (54286), chicken PRKG1 (423682), Horse PRKG1 (100071872), naked mole-rat Prkg1 (101708361), sheep PRKG1 (100294616), sheep PRKG1 (101117124), domestic cat PRKG1 (101097420), domestic guinea pig Prkg1 (100734084) ...Più
ID UniProtKB:
Q13976, E2PU10, P14619, Q5JSJ6, Q6P5T7
ID gene:
  • Human(5592) Summary: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
  • Mouse(19091) protein kinase, cGMP-dependent, type I
  • Rat(54286) protein kinase, cGMP-dependent, type 1
  • chicken(423682) protein kinase, cGMP-dependent, type I
  • Horse(100071872) protein kinase, cGMP-dependent, type I
  • naked mole-rat(101708361) protein kinase, cGMP-dependent, type I
  • sheep(100294616) protein kinase, cGMP-dependent, type I
  • sheep(101117124) protein kinase, cGMP-dependent, type I
  • domestic cat(101097420) protein kinase, cGMP-dependent, type I
  • domestic guinea pig(100734084) protein kinase, cGMP-dependent, type I
  • dog(609616) protein kinase, cGMP-dependent, type I
  • Domestic Rabbit(100008694) protein kinase, cGMP-dependent, type I
  • cow(282004) protein kinase, cGMP-dependent, type I

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ELISA

Numero di prodotto
Descrizione
Specie
CG201
cGMP Enzyme Immunoassay Kit, sufficient for 96 assays,
Specie
human
CG200
cGMP Enzyme Immunoassay Kit, Direct, sufficient for 96 assays,
Specie
human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
09-101
Anti-cGMP (cyclic GMP) Antibody, serum, Upstate®,
Reattività con
all
Applicazione
ELISA
immunohistochemistry
radioimmunoassay
HPA007699
Anti-PRKG1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
SAB1404246
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 5E5, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
western blot
SAB1306183
ANTI-CGKI (CGKI BETA)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human, mouse
Applicazione
immunohistochemistry
western blot
WH0005592M3
Monoclonal Anti-PRKG1 antibody produced in mouse, clone 2B3, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunohistochemistry
western blot

Proteins

Numero di prodotto
Descrizione
Specie
14-688-M
PKG1α Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1α. For use in Kinase Assays.,
Specie
human
P3738
Protein Kinase G Iβ human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution,
Specie
human
SRP0371
PKG1alpha active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Specie
human
14-650-M
PKG1β Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, full length PKG1β, for use in Kinase Assays.,
Specie
human
R8282
PRKG1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
EMU035791
MISSION® esiRNA, targeting mouse Prkg1,
Specie
mouse
EHU145811
MISSION® esiRNA, targeting human PRKG1,
Specie
human