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Merck

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

Sinonimi:
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD
Specie:
ID UniProtKB:
ID gene:
  • Human(776) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
  • Mouse(12289) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Rat(29716) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • sheep(101106371) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic cat(101088394) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Domestic Rabbit(100327259) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • chicken(395895) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Horse(100051186) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • dog(484724) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic guinea pig(100726255) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • cow(408013) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • naked mole-rat(101714832) calcium channel, voltage-dependent, L type, alpha 1D subunit

Custom & Knockdown Gene Products

Small Molecule - Allosteric Modulator

Numero di prodotto
Descrizione
Specie
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
Nimodipine, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Nimodipine, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Cinnarizine, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Felodipine, British Pharmacopoeia (BP) Reference Standard,
Specie
human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-CACNA1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Monoclonal Anti-CACNA1D antibody produced in mouse, clone S48A-9, 1 mg/mL, purified immunoglobulin,
Reattività con
human, mouse, rat
Applicazione
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reattività con
mouse, rat
Applicazione
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Numero di prodotto
Descrizione
Specie
Margatoxin, ,
Specie
mouse, rat, human
Amlodipine besylate, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Amlodipine besylate, ≥98% (HPLC),
Specie
human
Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Verapamil hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human CACNA1D,
Specie
human