1176506

Dexamethasone acetate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Dexamethasone 21-acetate, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate
• Empirical Formula (Hill Notation): C₂₄H₃₁FO₆
• CAS Number: 1177-87-3
• Molecular Weight: 434.50
• Beilstein: 2342608
• MDL number: MFCD00027407
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749549
• NACRES: NA.24

Properties

• biological source: synthetic
• grade: pharmaceutical primary standard
• Agency: USP
• vapor pressure: <0.0000001 kPa ( 25 °C)
• API family: dexamethasone
• form: powder
• packaging: pkg of 200 mg
• manufacturer/tradename: USP
• color: white
• mp: 460.4-464 °F (238—240°C)
• solubility: acetone: freely soluble; dichloromethane: slightly soluble; methanol: freely soluble; water: practically insoluble
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O
• InChI: 1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
• InChI key: AKUJBENLRBOFTD-RPRRAYFGSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids,[1] commonly used as a pharmaceutical ingredient in creams,[2] ointments,[3] microemulsions, lotions, aerosols, etc.[4]
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone acetate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Betamethasone Acetate
• Ciprofloxacin and Dexamethasone Otic Suspension
• Dexamethasone
• Dexamethasone Acetate
• Dexamethasone Acetate Injectable Suspension

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360FD
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable