SML0509

JK-P3

≥98% (HPLC)

• Synonym(s): 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
• Empirical Formula (Hill Notation): C₁₈H₁₇N₃O₃
• CAS Number: 942655-44-9
• Molecular Weight: 323.35
• MDL number: MFCD22666405
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825518
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1OC)C(=O)Nc2cc([nH]n2)-c3ccccc3
• InChI: 1S/C18H17N3O3/c1-23-15-9-8-13(10-16(15)24-2)18(22)19-17-11-14(20-21-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,19,20,21,22)
• InChI key: QAZJUVDICQNITG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

JK-P3 is a VEGFR-2 inhibitor.

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC₅₀ = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable