Anti-USP30 Antibody detects endogenous levels of total USP30 protein.
USP30 (ubiquitin specific peptidase 30) is ubiquitin-specific deubiquitylase. It is located in the mitochondria. It is mapped to human chromosome 12q24.
Immunogen
The antiserum was produced against synthesized peptide derived from human USP30.
Immunogen Range: 31-80
Application
Anti-USP30, N-Terminal antibody has been used in western blotting.
Biochem/physiol Actions
USP30 controls atypical ubiquitin chains on mitochondria and PARK2 (parkinson juvenile disease protein 2) mediated mitophagy.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously reported that auranofin, a gold(I)-containing agent
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