Ring finger protein 216 (RNF216) is an E3 ubiquitin ligase. The gene encoding this protein is localized on human chromosome 7p22.3.
Immunogen
TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
Biochem/physiol Actions
Ring finger protein 216 (RNF216) associates with toll-like receptors and aids in their degradation. It also aids in the degradation of receptor interacting protein-1 (RIP-1) kinase and negatively modulates tumor necrosis α receptor signaling. The protein acts as an inhibitor of autophagy in macrophages. Mutations in the RNF216 gene have been associated with Gordon Holmes syndrome.
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500315.
Physical form
Supplied in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination.
Xu C
Autophagy (2014)
Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-?B signaling.
Miah SM
Journal of Immunology (2011)
RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder.
Santens P
Neurology (2015)
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