This material is sold based on Sigma Units. One Sigma Unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units.
H8891
Heparinase III from Flavobacterium heparinum
Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)
Synonym(s):
Heparin Lyase III, Heparitinase I, Heparitinase from Flavobacterium heparinum
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5 UNITS
HUF 113,000.00
10 UNITS
HUF 172,000.00
50 UNITS
HUF 783,000.00
HUF 113,000.00
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5 UNITS
HUF 113,000.00
10 UNITS
HUF 172,000.00
50 UNITS
HUF 783,000.00
About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
HUF 113,000.00
Please contact Customer Service for Availability
Recommended Products
biological source
bacterial (Flavobacterium heparinum)
Quality Level
conjugate
conjugate (Glucosaminoglycan)
form
lyophilized powder
specific activity
≥30 units/mg protein (enzyme + BSA)
mol wt
70.8 kDa
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
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Application
Biochem/physiol Actions
Heparinase III prevents the formation of new blood vessels in vivo.[4] It specifically degrades heparin sulphate at the HNY-I and HNY,6X-G2 links. Unlike other heparinise, heparinase III does not contain the amino acid cysteine. It contains 13 histidine residues, which is responsible for its catalytic action.[5] This enzyme is not active towards heparin or low molecular weight heparins.
Heparin-degrading lyase that recognizes heparin sulfate proteoglycan as its primary substrate.
Unit Definition
One unit will form 0.1 μmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units. Package sizes are sold in Sigma units.
Other Notes
View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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Is Product No. H8891, Heparinase III sold based on Sigma Units or International Units?
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Does Product No. H8891, Heparinase III, contain calcium?
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This product is lyophilized from a solution which is 75 mM NaCl/ 5mM NaH2PO4. We have no reason to believe that calcium ions are present.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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