G4274
Globoside from human erythrocytes
≥95%
Synonym(s):
Globotetraosylceramide
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biological source
human erythrocytes
Assay
≥95%
form
film
functional group
amide
hydroxyl
shipped in
ambient
storage temp.
−20°C
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Josefine Betz et al.
Biological chemistry, 393(3), 133-147 (2012-06-22)
Membrane microdomain association of the glycosphingolipids (GSLs) globotriaosylceramide (Gb3Cer) and globotetraosylceramide (Gb4Cer), the highly and less effective receptors, respectively, for Shiga toxins (Stxs), is assumed as a functional requirement for Stx-mediated cytotoxicity. In a previous study, we demonstrated predominant localization
D H Jones et al.
Biochemistry, 36(28), 8539-8547 (1997-07-15)
Recognition of macromolecules by glycosphingolipids is closely correlated with the nature of the glycolipid carbohydrate; however, it is also thought to be secondarily modulated by the structure of the single fatty acid. In the present work, we sought insight into
Yunsen Li et al.
Glycobiology, 18(2), 158-165 (2007-12-07)
Glycosphingolipids serve as ligands for receptors involved in signal transduction and immune recognition, as exemplified by isoglobotrihexosylceramide, an antigenic ligand for T cell receptors. Mechanistic studies on the regulation of isoglobotrihexosylceramide require biochemical measurement of its lysosomal precursor, isoglobotetraglycosylceramide. It
Tetsuya Okuda
International journal of molecular sciences, 21(10) (2020-05-28)
Glycosphingolipids containing very-long-chain fatty acids (VLCFAs) regulate several immune responses, such as cytokine production, immune signaling, and antibody induction. We previously reported that stimulation with an inflammatory mediator, TNF-α, promotes the expression of glycosphingolipids in vascular endothelial cells. The major
Y Song et al.
The Journal of biological chemistry, 273(5), 2517-2525 (1998-02-28)
Undifferentiated human embryonal carcinoma cells are characterized by high expression of lactoneotetraosylceramide (nLc4), globoside (Gb4), and extended globo-series glycosphingolipids (GSLs) termed "stage-specific embryonic antigens 3 and 4" (SSEA-3 and -4). Expression of these GSLs declines in association with a decline
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