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EMU036241

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Ap1m2

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20 μG
HUF 75,800.00
50 μG
HUF 135,000.00

HUF 75,800.00

Please contact Customer Service for Availability
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20 μG
HUF 75,800.00
50 μG
HUF 135,000.00

About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

HUF 75,800.00

Please contact Customer Service for Availability

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

ATCACACAACAGGGCAACAAGCTGGAGACTGGCAAATCTCGTGTACCACCTACAGTCACCAATGCGGTGTCGTGGCGCTCTGAGGGCATTAAGTACAAAAAGAATGAGGTCTTCATTGATGTCATTGAGTCTGTCAACCTTCTGGTCAATGCTAATGGGAGTGTCTTGCTCAGCGAGATTGTGGGCACCATCAAGCTGAAGGTGTTTCTGTCTGGGATGCCAGAGCTGCGGCTGGGCCTCAATGACCGAGTGCTCTTTGAGCTTACTGGCCGCAGCAAGAACAAGTCTGTGGAACTGGAAGATGTGAAATTCCACCAATGTGTGAGGCTTTCACGCTTTGACAACGACCGAACCATCTCCTTCATACCCCCAGATGGGGACTTTGAACTCATGTCCTACCGGCTTAGCACCCAGGTCAAACCCCTGATCTGGATCGAGTCAGTCATTGAGAAATTCTCGCACAGCCGAGTGGAGATCATGGTGAAGGCCAAG

Ensembl | mouse accession no.

ENSMUSG00000003309

NCBI accession no.

NM_009678

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... AP1M2(11768) , Ap1m2(11768)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Biochem/physiol Actions

Ap1m2 (AP-1 complex subunit μ-2) is a μ1B subunit of AP-1B (adaptor protein). In polarised epithelial cells, AP-1B is responsible for basolateral sorting of membrane proteins. Absence of the Ap1m2 gene in mice results in T-helper (Th)17-dominant colitis and intestinal epithelial cell hyperplasia. Ap1m2 is associated with expression of antimicrobial proteins and the luminal transport of secretory IgA (immunoglobulin A).[1][2]

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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KSU
KRU

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The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.
Takahashi D
Gastroenterology, 141, 621-621 (2011)
AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.
Hase K
Gastroenterology, 145, 625-625 (2013)

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