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E2895

Sigma-Aldrich

(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide

≥98%

Synonym(s):

NOR-3

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10 MG
HUF 127,000.00

HUF 127,000.00

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10 MG
HUF 127,000.00

About This Item

Empirical Formula (Hill Notation):
C8H13N3O4
CAS Number:
138472-01-2
Molecular Weight:
215.21
MDL number:
MFCD00270892
UNSPSC Code:
12352200
PubChem Substance ID:
329799038
NACRES:
NA.77

HUF 127,000.00

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Quality Level

100

Assay

≥98%

form

powder

solubility

DMSO: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC\C(=C/C(=N\O)C(N)=O)C(C)[N+]([O-])=O

InChI

1S/C8H13N3O4/c1-3-6(5(2)11(14)15)4-7(10-13)8(9)12/h4-5,13H,3H2,1-2H3,(H2,9,12)/b6-4+,10-7+

InChI key

MZAGXDHQGXUDDX-AGLLBGTNSA-N

Related Categories

Application

Cell-permeable NO donor; releases nitric oxide spontaneously in a rate-controlled manner. Half-life in solution = 30 min.

Biochem/physiol Actions

Activates intracellular guanylyl cyclase.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7230
MKCQ3481
MKBW5539V
MKBR3847V
SLBJ4694V

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Tomáš Macháček et al.
Parasites & vectors, 13(1), 426-426 (2020-08-21)
Avian schistosomes, the causative agents of human cercarial dermatitis (or swimmer's itch), die in mammals but the mechanisms responsible for parasite elimination are unknown. Here we examined the role of reactive nitrogen species, nitric oxide (NO) and peroxynitrite, in the
Y Kita et al.
European journal of pharmacology, 257(1-2), 123-130 (1994-05-12)
(+-)-(E)-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide (FK409), which was isolated from microbial products, has been reported to show a vasorelaxant effect through a mechanism similar to that of the organic nitrates such as isosorbide dinitrate. In solution at pH 7.4, FK409 decomposed and released nitric
Elsa Cortés-Montero et al.
Antioxidants & redox signaling, 31(7), 503-520 (2019-05-16)
Aims: Histidine triad nucleotide-binding protein 1 (HINT1) exhibits proapoptotic and tumor-suppressive activity. HINT1 binds to transcription factors such as

Articles

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

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