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D103

Sigma-Aldrich

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Synonym(s):

DCMB, LY-78335

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About This Item

Empirical Formula (Hill Notation):
C8H9Cl2N · HCl
CAS Number:
39226-94-3
Molecular Weight:
226.53
MDL number:
MFCD00055225
UNSPSC Code:
12352202
PubChem Substance ID:
24278157
Pricing and availability is not currently available.

form

solid

color

white

solubility

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

SMILES string

Cl[H].CC(N)c1cccc(Cl)c1Cl

Gene Information

human ... PNMT(5409)

Biochem/physiol Actions

PNMT inhibitor.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S P Kalra
Neuroendocrinology, 40(2), 139-144 (1985-02-01)
Adult female rats were implanted with permanent cannulae in the third ventricle of the brain and allowed to recover regular 4-day estrous cycles. They received intrajugular cannulae on the morning of proestrus and later between 12.00-13.00 h catecholamines - norepinephrine
Lowering of epinephrine concentration in rat brain by 2,3-dichloro-alpha-methyl-benzylamine, an inhibitor of norepinephrine N-methyltransferase.
R W Fuller et al.
Biochemical pharmacology, 26(21), 2087-2090 (1977-11-01)
N Y Liang et al.
Research communications in chemical pathology and pharmacology, 37(3), 445-452 (1982-09-01)
Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats. In the drug-treated animals, the time course for reduction of body temperature was better correlated
M Kuboia et al.
Neuropsychobiology, 33(3), 132-137 (1996-01-01)
This study examines the in vivo effects of 2,3-dichloro-alpha-methylbenzylamine (DCMB), a centrally active phenylethanolamine-N-methyltransferase (PNMT) inhibitor, on alpha 2-adrenoceptors. Sixty-six rats received either DCMB, SKF29661, the peripheral PNMT inhibitor, at a dose of 50 mg/kg or saline intraperitoneally. To examine
B A Adler et al.
Endocrinology, 113(4), 1431-1438 (1983-10-01)
Results from previous investigations have suggested an important role for central epinephrine (EPI) systems in mediating the stimulatory effects of ovarian hormones on LH release in ovariectomized female rats. The purpose of these experiments was 1) to test whether selective
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