C9650
β-Cyano-L-alanine
≥95%, suitable for ligand binding assays
Synonym(s):
3-cyano-L-alanine
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250 MG
HUF 240,000.00
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250 MG
HUF 240,000.00
About This Item
Empirical Formula (Hill Notation):
C4H6N2O2
CAS Number:
Molecular Weight:
114.10
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
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Product Name
β-Cyano-L-alanine, ≥95%
Assay
≥95%
form
powder
technique(s)
ligand binding assay: suitable
color
white
mp
217 °C
storage temp.
−20°C
SMILES string
OC([C@@H](N)CC#N)=O
InChI
1S/C4H6N2O2/c5-2-1-3(6)4(7)8/h3H,1,6H2,(H,7,8)/t3-/m0/s1
InChI key
BXRLWGXPSRYJDZ-VKHMYHEASA-N
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Biochem/physiol Actions
β-Cyano-L-alanine (BCA) is used as a cystathione γ-lyase (CSE) inhibitor to study the physiological roles of hydrogen sulfide in processes such as angiogenesis and hypertension.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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R Miura et al.
Journal of biochemistry, 87(5), 1469-1481 (1980-05-01)
The reaction of D-amino acid oxidase [EC 1.4.3.3] (DAO) from porcine kidney with beta-cyano-D-alanine (D-BCNA) was studied. DAO was found to catalyze elimination of the cyano group as well as oxidation of D-BCNA. During the course of the reaction in
Ying-Yuan Pamela Mok et al.
British journal of pharmacology, 143(7), 881-889 (2004-10-27)
Haemorrhagic shock (60 min) in the anaesthetized rat resulted in a prolonged fall in the mean arterial blood pressure (MAP) and heart rate (HR). Pre-treatment (30 min before shock) or post-treatment (60 min after shock) with inhibitors of cystathionine gamma
K Witthohn et al.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 79(1), 103-106 (1984-01-01)
Beside the known existence of cyanoglucosides (linamarin and lotaustralin) and proteins the neurotoxin beta-cyanoalanine has been demonstrated for the first time in the defensive secretions of animals. It is proposed that beta-cyanoalanine is produced by metabolizing cyanide from the cyanoglucosides.
Tadahiko Masaki et al.
Journal of gastroenterology, 38(1), 37-44 (2003-02-01)
The clinical utility of relative and absolute grading criteria for submucosal invasion in T1 colorectal carcinomas has been controversial. In 51 T1 colorectal carcinomas, depth of submucosal invasion was graded either according to a modified Haggitt's classification (a relative criterion)
B Teague et al.
British journal of pharmacology, 137(2), 139-145 (2002-09-05)
1. Sodium hydrogen sulphide (NaHS), a donor of hydrogen sulphide (H(2)S), produced dose-related relaxation of the rabbit isolated ileum (EC(50), 76.4+/-7.9 microM) and rat vas deferens (EC(50), 64.8+/-5.4 microM) and reduced ACh-mediated contraction of the guinea-pig isolated ileum. 2. NaHS
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