Based on our quality control testing, Corticotropin Releasing Factor human, rat (C3042) is soluble in water at a concentration of 1 mg/ml.
C3042
Corticotropin Releasing Factor human, rat
≥95% (HPLC), powder
Synonym(s):
CRF, CRH
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0.1 MG
HUF 66,200.00
250 μG
HUF 134,000.00
0.5 MG
HUF 228,000.00
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0.1 MG
HUF 66,200.00
250 μG
HUF 134,000.00
0.5 MG
HUF 228,000.00
About This Item
Empirical Formula (Hill Notation):
C208H344N60O63S2
CAS Number:
Molecular Weight:
4757.45
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
rat
Quality Level
Assay
≥95% (HPLC)
form
powder
mol wt
4757.45
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
solubility
water: 1.00-1.04 mg/mL, colorless
UniProt accession no.
storage temp.
−20°C
InChI key
VXFVFWFSJFSXHN-FAUHKOHMSA-N
Gene Information
human ... CRH(1392)
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Amino Acid Sequence
Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
General description
Application
Corticotropin Releasing Factor human, rat has been used:
- as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants[3]
- as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells[4]
- in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture[5]
- in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus[6]
Biochem/physiol Actions
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses.[7][1] It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.[8]Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[9] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[10]
Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.
Other Notes
Lyophilized from 0.1% TFA in H2O
antibody
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
A Slominski
The British journal of dermatology, 160(2), 229-232 (2009-02-04)
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation
Simard M, et al.
Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)
Salt appetite
Vitamins & Hormones (2017)
Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone
Thome UH, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 284(2), L376-L385 (2003)
Anxiolytics.
Handbook of Clinical Neurophysiology, 106, 669-669 (2012)
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What is the solubility of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
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What is the solution stability of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
Sigma has not tested Corticotropin Releasing Factor human, rat (C3042) for solution stability or for stability in culture. The following article looks at the stability of corticotropin releasing factor: Acta Med Okayama. 1985 Jun;39(3):199-206.
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What is the difference between the peptide content and the purity of Corticotropin Releasing Factor human, rat (C3042)?
1 answer-
The peptide content of Corticotropin Releasing Factor human, rat (C3042) is determined by amino acid analysis (AAA) and distinguishes how much of the product is actually peptide. The purity of Corticotropin Releasing Factor human, rat (C3042) is determined by HPLC and distinguishes how much of the peptide found is Corticotropin Releasing Factor human, rat (C3042).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the counter ion in Corticotropin Releasing Factor human, rat (C3042)?
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Corticotropin Releasing Factor human, rat (C3042) is lyophilized from 0.1% TFA in water.
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