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51947

Sigma-Aldrich

N-Acetyl-D-galactosamine 6-sulfate sodium salt

≥98.0% (TLC)

Synonym(s):

GalNAc-6S

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About This Item

Linear Formula:
C8H14O9NSNa
CAS Number:
204575-07-5
Molecular Weight:
323.25
MDL number:
MFCD00214239
UNSPSC Code:
12352201
PubChem Substance ID:
329757768

biological source

bovine (Ruminant- Cow, Ox, Buffalo)

Quality Level

100

description

Mixed anomers

Assay

≥98.0% (TLC)

form

solid

optical activity

[α]/D 54.0±4.0, c = 0.1% (w/v) in water

technique(s)

thin layer chromatography (TLC): suitable

storage temp.

−20°C

SMILES string

[Na+].CC(=O)N[C@H]1C(O)O[C@H](COS([O-])(=O)=O)[C@H](O)[C@@H]1O

InChI

1S/C8H15NO9S.Na/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16;/h4-8,11-13H,2H2,1H3,(H,9,10)(H,14,15,16);/q;+1/p-1/t4-,5-,6+,7-,8?;/m1./s1

InChI key

CBUJZKTVEFVBBG-DBKUKYHUSA-M

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Application

N-Acetyl-D-galactosamine 6-sulfate (GalNAc-6S) is used as a substrate to identify, differentiate and characterize N-acetylgalactosamine sulfatase(s). GalNAc-6S is used to study the rare autosomal recessive disorder Mucopolysaccharidosis IVA (MPS IVA).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBN4984V
BCBK3020V
BCBK9592V
1443260
1432003

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S Tomatsu et al.
Current pharmaceutical biotechnology, 12(6), 931-945 (2011-04-22)
Mucopolysaccharidosis IVA (MPS IVA), also known as Morquio A, is a rare, autosomal recessive disorder caused by a deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate-sulfatase (GALNS), which catalyzes a step in the catabolism of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate
Souhir Khedhiri et al.
Diagnostic pathology, 6, 11-11 (2011-01-22)
Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes. At least, 148 mutations and 16 polymorphisms were identified in the GALNS gene.The aim of
G J Gibson et al.
The Biochemical journal, 248(3), 755-764 (1987-12-15)
Initial purification of N-acetylgalactosamine-4-sulphate sulphatase from human liver homogenates containing approx. 1 mg of enzyme in 26 g of soluble proteins was achieved by a six-column chromatography procedure and yielded approx. 40 micrograms of a single major protein species. Enzyme
J Bielicki et al.
The Biochemical journal, 279 ( Pt 2), 515-520 (1991-10-15)
Human N-acetylgalactosamine 6-sulphatase (EC 3.1.6.14), which is involved in the lysosomal degradation of the glycosaminoglycans keratan sulphate and chondroitin 6-sulphate, was purified more than 130,000-fold in 2.8% yield from liver by an eight-step column procedure. One major form was identified
M Masue et al.
Journal of biochemistry, 110(6), 965-970 (1991-12-01)
N-Acetylgalactosamine-6-sulfate sulfatase from human placenta was purified 33,600-fold using beta-N-acetyl-D-galactosamine 6-sulfate-(1----4)-beta-D-glucuronic acid-(1----3)-N-acetyl-D-[3H]galactosaminitol 6-sulfate as the substrate. This enzyme is an oligomer with a molecular mass of 120 kDa and consists of polypeptides of 40 and 15 kDa. The 15 kDa
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