Langmuir : the ACS journal of surfaces and colloids, 26(2), 1239-1246 (2009-09-03)
The immobilization of biological species such as proteins and enzymes in sol-gel hosts is currently an area of intense research activity. However, the majority of these studies have been directed toward investigating the biological activity or physicochemical properties of the
Microchip-based CEC of nitroaromatic and nitramine explosives with UV absorbance detection is described. The stationary phase was deposited in the microchip using the sol-gel process. Unique to this work, is the exclusive use of alkylated-trimethoxysilane precursors in the gel solution.
Journal of chromatography. A, 1174(1-2), 50-62 (2007-11-21)
Sol-gel coating with covalently bonded low-molecular-weight (MW<300 Da) poly(ethylene glycol) (PEG) chains was developed for capillary microextraction (CME). The sol-gel chemistry proved effective in the immobilization of low-molecular-weight PEGs thanks to the formation of chemical bonds between the organic-inorganic hybrid
Methods in molecular biology (Clifton, N.J.), 632, 221-237 (2010-03-11)
Due to poor drug candidate safety profiles that are often identified late in the drug development process, the clinical progression of new chemical entities to pharmaceuticals remains hindered, thus resulting in the high cost of drug discovery. To accelerate the
Chemistry (Weinheim an der Bergstrasse, Germany), 17(5), 1696-1704 (2011-01-27)
The main objective of this study was to develop a new methodology for the preparation of a protein (antigen) that is a molecularly imprinted polymer (MIP, an artificial antibody) modified onto the surface of a silica skeleton in which the
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