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Key Documents

23-057-M

Sigma-Aldrich

Smac/DIABLO

Synonym(s):

Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase (Smac)

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10 μG
HUF 227,000.00
250 μG
HUF 1,300,000.00

HUF 227,000.00

Estimated to ship onMarch 31, 2025Details

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Select a Size

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10 μG
HUF 227,000.00
250 μG
HUF 1,300,000.00

About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

HUF 227,000.00

Estimated to ship onMarch 31, 2025Details

biological source

human

Quality Level

100

form

liquid

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

NCBI accession no.

NM_019887

General description

Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and disrupts the ability of the IAPs to inhibit caspases 3, 7, and 9 thereby promoting apoptosis. Along with several other pro-apoptotic proteins, Smac/DIABLO has been shown to be a substrate for the ubiquitin ligase XIAP.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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