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D-079

Supelco

Demoxepam solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15H11ClN2O2
CAS Number:
963-39-3
Molecular Weight:
286.71
MDL number:
MFCD00868147
UNSPSC Code:
41116107
PubChem Substance ID:
329798639
NACRES:
NA.24
Pricing and availability is not currently available.

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

ClC1=CC=C(NC(C[N+]([O-])=C2C3=CC=CC=C3)=O)C2=C1

InChI

1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19)

InChI key

GGRWZBVSUZZMKS-UHFFFAOYSA-N

Related Categories

General description

A benzodiazepine drug and anticonvulsant, demoxepam is also a primary metabolite of chlordiazepoxide, marketed as Klopoxid or Librax® for the treatment of anxiety and muscle spasms or pain.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Librax is a registered trademark of Valeant Pharmaceuticals North America LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup

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U A Brinkman et al.
Journal of chromatography, 217, 463-471 (1981-11-06)
Upon irradiation with short-wavelength UV light the tranquillizer demoxepam is converted into a highly fluorescent product. This reaction serves as a sensitive and selective means of detection of low levels of demoxepam in e.g., serum after separation by means of
T J Good et al.
Journal of chromatographic science, 19(11), 562-566 (1981-11-01)
A simple, rapid method for the determination of the benzodiazepines, diazepam and chlordiazepoxide, and their metabolites by high performance liquid chromatography (HPLC) has been developed. The procedure is applicable to the assay of other similar drugs in biological fluids. The
Christiaan H Vinkers et al.
Psychopharmacology, 208(4), 555-562 (2010-01-13)
In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solution has been described. This would diminish plasma levels in chronic minipump studies
H Essien et al.
Journal of chromatography. B, Biomedical applications, 683(2), 199-208 (1996-08-30)
The identification of the metabolite demoxepam in human urine establishes that chlordiazepoxide, a common benzodiazepine, has been administered. Like N-oxide metabolites of other drugs, demoxepam cannot be detected by gas chromatography-mass spectrometry (GC-MS), due to thermal decomposition, and the product
Moustapha Ouédraogo et al.
Drug and chemical toxicology, 32(4), 417-423 (2009-10-02)
The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan. For the
View All Related Papers

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