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900948

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA Mn 15,000, lactide:glycolide 50:50

Synonym(s):

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA

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1 G
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1 G
HUF 121,000.00

About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
51171641
NACRES:
NA.23

HUF 121,000.00

Please contact Customer Service for Availability
Request a Bulk Order

form

crystals

Quality Level

100

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 5,000
PLGA Mn 15,000

impurities

≤5000 ppm (GC)

storage temp.

−20°C

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900842900949900950
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 5,000, PLGA Mn 15,000, lactide:glycolide 50:50

900948

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 5,000, PLGA Mn 15,000, lactide:glycolide 80:20

900842

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 5,000, PLGA Mn 20,000, lactide:glycolide 50:50

900949

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 5,000, PLGA Mn 5,000, lactide:glycolide 50:50

900950

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mol wt

PEG average Mn 5,000, PLGA Mn 15,000

mol wt

PEG average Mn 5,000, PLGA Mn 15,000

mol wt

PEG average Mn 5,000, PLGA Mn 20,000

mol wt

PEG average Mn 5,000, PLGA Mn 5,000

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

impurities

≤5000 ppm (GC)

impurities

≤500 ppm (GC)

impurities

-

impurities

≤5000 ppm (GC)

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 80:20

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

General description

Contains ≤500 ppm impurities by GC, including trace monomer and residual organics.

Application

Biocompatible block copolymer. Can be used in the formation of nanoparticles for drug delivery. Potenial use in the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

>230.9 °F

Flash Point(C)

> 110.5 °C

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP5053
MKCL4610
MKCD7197

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Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their

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