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348147

Sarsasapogenin

Name: Sarsasapogenin
Brand: ALDRICH

95%

Synonym(s):

(25S)-Spirostan-3β-ol, Parigenin

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₄₄O₃

CAS Number:

126-19-2

Molecular Weight:

416.64

MDL number:

MFCD00270414

UNSPSC Code:

12352200

PubChem Substance ID:

329755058

Pricing and availability is not currently available.

Assay

95%

form

solid

SMILES string

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

InChI key

GMBQZIIUCVWOCD-WWASVFFGSA-N

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Lot/Batch Number

07202HW

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Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.

Yaer Hu et al.

Neurobiology of aging, 31(6), 1010-1019 (2008-08-05)

The purpose of this work is to study the effect of smilagenin on the mRNA stability of muscarinic receptor subtype 1 (M(1); m1 mRNA) in aged rat brains and its significance in improving memory. The Y-maze avoidance task showed that

Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging.

Haiyan Hu et al.

FEBS letters, 584(8), 1549-1552 (2010-03-11)

This work studied the role of cyclic AMP responsive element binding protein (CREB) in the up-regulation of M(1) muscarinic acetylcholine receptor (M(1) receptor) density by sarsasapogenin (ZMS) in CHO cells transfected with M(1) receptor gene (CHOm1 cells). During cell aging

Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells.

Hua Zhou et al.

Molecular and cellular endocrinology, 270(1-2), 17-22 (2007-03-17)

We investigated the effect of tigogenin on adipocytic and osteoblastic differentiation in mouse bone marrow stromal cells (BMSCs). Tigogenin enhanced the proliferation of BMSCs significantly. Tigogenin treatment reduced the adipogenic induction of lipid accumulation, visfatin secretion, and the expressions of

Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.

Bertrand Liagre et al.

International journal of molecular medicine, 20(4), 451-460 (2007-09-06)

We conducted our study to assess the antiproliferative and proapoptotic potential of hecogenin and tigogenin, two saponins which are structurally similar to diosgenin. We particularly focused our attention on mitogen-activated protein kinase (MAPK) activation in relation to apoptosis but also

Steroids from the roots of Asparagus officinalis and their cytotoxic activity.

Xue-Feng Huang et al.

Journal of integrative plant biology, 50(6), 717-722 (2008-08-21)

One new (Sarsasapogenin O) and seven known steroids were isolated from the roots of Asparagus officinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known

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