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T133

Sigma-Aldrich

Inactin® hydrate

≥98% (HPLC)

Sinónimos:

Thiobutabarbital sodium salt hydrate

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About This Item

Fórmula empírica (notación de Hill):
C10H15N2NaO2S · xH2O
Número de CAS:
947-08-0
Peso molecular:
250.29 (anhydrous basis)
EC Number:
213-425-3
MDL number:
MFCD00214068
UNSPSC Code:
12352200
PubChem Substance ID:
24899957
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

color

light yellow

solubility

H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)

SMILES string

[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O

InChI

1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1

InChI key

SLZHLQUFNFXTHB-UHFFFAOYSA-M

Application

Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).

Biochem/physiol Actions

Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.

Legal Information

Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000356567
0000356568
0000331881
0000331879
0000356568

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Eman Y Gohar et al.
Journal of the American Heart Association, 9(10), e015110-e015110 (2020-05-12)
Background The novel estrogen receptor, G-protein-coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt-induced complications, yet there is no direct evidence for GPER control of renal Na+ handling. We hypothesized
Haiyun Qi et al.
Magnetic resonance in medicine, 80(5), 2073-2080 (2018-03-10)
Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in
J Buelke-Sam et al.
Laboratory animal science, 28(2), 157-162 (1978-04-01)
Rats were anesthetized with pentobarbital, pentobarbital and atropine, inactin [5-ethyl-5-(1'-methyl-propyl)-2-thiobarbiturate], ether and inactin, or urethane. Cardiovascular and arterial acid-base parameters were monitored over a 3-hour period of anesthesia. Heart rate, arterial pressures, and pH progressively decreased with duration of pentobarbital
Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
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