D3900

Desipramine hydrochloride

≥98% (TLC), powder, imipramine metabolite

• Fórmula empírica (notación de Hill): C₁₈H₂₂N₂ · HCl
• Número de CAS: 58-28-6
• Peso molecular: 302.84
• EC Number: 200-373-1
• MDL number: MFCD00058108
• UNSPSC Code: 12352116
• PubChem Substance ID: 24278094
• NACRES: NA.77

Propiedades

• Nombre del producto: Desipramine hydrochloride, ≥98% (TLC), powder
• Quality Level: 100
• assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• solubility: H₂O: 50 mg/mL
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
• InChI key: XAEWZDYWZHIUCT-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530)

Descripción

General description

Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.[1]

Application

Desipramine hydrochloride has been used:

• to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons[2]
• to protect unselective damage to the noradrenergic system[3]
• as a norepinephrine re-uptake inhibitor to treat rats for lesioning[4]

Biochem/physiol Actions

Desipramine is used to treat depression. It is also used to manage enuresis in children.[1] Desipramine helps to eliminate the pain triggered by diabetic neuropathy.[5]

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 4 nM) than the serotonin transporter (K_i = 61 nM).

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Caution

Hygroscopic

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H315,H317,H319,H334,H335
• pcodes: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves