N5751

N_ω-Nitro-L-arginine methyl ester hydrochloride

≥97% (TLC), powder, nitric oxide production inhibitor

• Sinónimos: L-NAME HCl, L-NAME hydrochloride
• Fórmula empírica (notación de Hill): C₇H₁₅N₅O₄ · HCl
• Número de CAS: 51298-62-5
• Peso molecular: 269.69
• Beilstein: 3744166
• Número CE: 257-116-1
• Número MDL: MFCD00039052
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24278011
• NACRES: NA.77

Propiedades

• Nombre del producto: N_ω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder
• origen biológico: synthetic
• Nivel de calidad: 200
• Ensayo: ≥97% (TLC)
• Formulario: powder
• color: white to off-white
• mp: 132 °C
• solubilidad: H₂O: 50 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
• InChI: 1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
• Clave InChI: QBNXAGZYLSRPJK-JEDNCBNOSA-N

Descripción

Descripción general

Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.

Aplicación

Nω-Nitro-L-arginine methyl ester hydrochloride has been used:

• to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
• to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
• to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells
• to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat

Acciones bioquímicas o fisiológicas

Arginine analog that inhibits NO production.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)