SML3715

SSK1

≥98% (HPLC)

• Sinónimos: (2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-((((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)oxy)methyl)-2-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
• Fórmula empírica (notación de Hill): C₃₁H₃₄F₂N₄O₁₈
• Número de CAS: 2629250-69-5
• Peso molecular: 788.61
• MDL number: MFCD34474020
• UNSPSC Code: 12352200
• NACRES: NA.21

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Descripción

Biochem/physiol Actions

SSK1 is a senescence cells specific killing agent that is activated by lysosomal β-galactosidase. SSK1 induces apoptosis in senescence cells through activation of p38 MAPK. Also, it induces mitochondrial DNA damage in senescent cells. In aged mice, SSK1 removes senescence cells in different tissues, attenuated low-grade inflammation and improved physical function.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable