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SML0583

Sigma-Aldrich

Ferrostatin-1

≥95% (HPLC), powder, non-apoptotic cell death inhibitor

Sinónimos:

3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;

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About This Item

Fórmula empírica (notación de Hill):
C15H22N2O2
Número de CAS:
347174-05-4
Peso molecular:
262.35
UNSPSC Code:
12352200
NACRES:
NA.77
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Nombre del producto

Ferrostatin-1, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

, faint purple to brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N

InChI

1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

InChI key

UJHBVMHOBZBWMX-UHFFFAOYSA-N

Application

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.[1][2]

Biochem/physiol Actions

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy.[3] Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.[4]

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000407155
0000407155
0000407157
0000368771
0000299749

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On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
Zilka O, et al.
ACS central science, 3(3), 232-243 (2017)
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai T T, et al.
Nature Chemistry, 9(10), 1025-1025 (2017)
The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.
Kabiraj P, et al.
The Protein Journal, 34(5), 349-358 (2015)
Rachel P L van Swelm et al.
Cell death & disease, 9(5), 550-550 (2018-05-12)
Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement
Farhan Basit et al.
Cell death & disease, 8(3), e2716-e2716 (2017-03-31)
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY') triggers death of BRAFV600E melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death.
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Questions

1–2 of 2 Questions  

  1. DMSOで溶解後の保存は冷蔵保存ですか？それとも冷凍保存でしょうか？

    1 answer

    1. Following reconstitution, stock solutions are stable up to 6 months when stored frozen in aliquots at -20°C.

      Helpful?

  2. What is the protocol for diluting SML0583 (5 mg), which is said to be soluble in DMSO? Additionally, what kind of stock solution can I prepare for long-term storage and where to store it after adding DMSO.

    1 answer

    1. The solubility of Ferrostatin-1 is approximately 10 mg/ml in DMSO. The detailed solution stability information is not available; therefore, it is recommended to prepare a fresh solution for each application.

      Helpful?

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