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Merck
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Key Documents

SCP0152

Sigma-Aldrich

Gastrin I (1-14)

≥92% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C79H100N16O27
Peso molecular:
1705.73
UNSPSC Code:
51111800
NACRES:
NA.32

assay

≥92% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp

General description

Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin.

Application

Gastrin I (1-14) has been used:
  • as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere culture
  • as a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO)
  • in viable lymphocytes culture for re-stimulation assay

Biochem/physiol Actions

Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells.
The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Zhi-Feng Miao et al.
Stem cells (Dayton, Ohio), 32(12), 3062-3074 (2014-08-22)
Peritoneal dissemination is the most common cause of death in gastric cancer patients. The hypoxic microenvironment plays a major role in controlling the tumor stem cell phenotype and is associated with patients' prognosis through hypoxia-inducible factor-1α (HIF-1α), a key transcriptional
Junjie Gao et al.
Rapid communications in mass spectrometry : RCM, 22(24), 4066-4072 (2008-11-21)
Negative ion production from peptides and proteins was investigated by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Although most research on peptide and protein identification with ionization by MALDI has involved the detection of positive ions, for some acidic peptides
C M Thorburn et al.
Gastroenterology, 115(2), 275-280 (1998-07-25)
Gastrin is a putative promoter of colorectal carcinomas. The aim of this study was to evaluate the temporal relationship between gastrinemia and development of colorectal malignancy. We conducted a nested case-control study among 128,992 subscribers to a health maintenance program
Gastrin
Handbook of Hormones (2016)
F L Lai Benjamin et al.
Advanced functional materials, 30(48) (2021-03-12)
Tumor progression relies heavily on the interaction between the neoplastic epithelial cells and their surrounding stromal partners. This cell cross-talk affects stromal development, and ultimately the heterogeneity impacts drug efflux and efficacy. To mimic this evolving paradigm, we have micro-engineered
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