R8781

Rapamycin

from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor

• Sinónimos: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution
• Fórmula empírica (notación de Hill): C₅₁H₇₉NO₁₃
• Peso molecular: 914.17
• Número CE: 200-664-3
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nombre del producto: Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
• origen biológico: Streptomyces hygroscopicus
• Nivel de calidad: 300
• presión de vapor: 0.56 hPa ( 20 °C)
• Ensayo: ≥95% (HPLC)
• Formulario: solution
• temp. de autoignición: 301 °C
• concentración: 2.5 mg/mL in DMSO (2.74 mM)
• color: colorless to yellow
• espectro de actividad antibiótica: fungi; yeast
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.

Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.

Aplicación

Rapamycin has been used:

• as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
• to treat the Drosophila S2 cells at 65-70% confluence,
• to measure protein synthesis
• to stimulate autophagy in ovarian cancer cells

Envase

200uL

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 188.6 °F - closed cup
• Punto de inflamabilidad (°C): 87 °C - closed cup
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)